Quarterly Newsletter

2014-August_IVG Newsletter-Toxicology-Interventional Analgesia

The IVG Hospitals Quarterly Veterinary Newsletter features articles of interest to the veterinary medical community, written by veterinarians and veterinary specialists at our four locations.

Issue link: http://ivghospitals.uberflip.com/i/371752

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Page 4 of 12

| 4 | Toxicity often occurs when pyrethroid products intended for dogs are mistakenly applied to cats. The onset of clinical signs usually occurs within 12-72 hours. Pyrethroids are fat soluble and rapidly metabolized. A minimum lethal dose has not been established for feline patients. It has been noted that cats exhibit an increased sensitivity to the effects of pyrethroids due to a decreased ability to hydrolyze esters as well as a deficiency in glucuronidase transferase. Treatment consists of initial decontamination via bathing with dilute dish detergent to remove topical products, IV fluid therapy and control of tremors via administration of muscle relaxants such as Methocarbamol that can be administered IV at a dose of 50-150mg/kg and not to exceed 300 mg/kg/day. Diazepam does not work as effectively to reduce tremors. Patients can also experience rapid changes in body temperature as a result of ongoing tremoring and bathing, and require close monitoring. Intravenous lipid emulsion therapy has recently been successfully utilized in cases of pyrethroid toxicity and may reduce the duration of the patient's hospitalization. Table 2 (above) features examples of commonly prescribed products, as well as those that are intended only for canine patients. Table 2: Commonly administered antiparasitic products

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